Key result
Aripiprazole initiation is linked to psychosis exacerbation in 4 clinical cases.
Why the study?
Aripiprazole is a partial dopamine D2 receptor agonist that might theoretically worsen psychosis, but clinical evidence is limited.
Does aripiprazole worsen psychosis in patients with psychotic disorders?
Population
4 clinical cases of patients with psychosis
Comparison
Aripiprazole initiation while tapering or added to atypical antipsychotic
Design
Case series
Authors
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May warrant monitoring for psychosis worsening with aripiprazole start; case reports leave open causality and generalizability.
Case Report (n=4)
Does aripiprazole worsen psychosis in patients with psychotic disorders?
Aripiprazole initiation may be associated with worsening of psychosis in some patients, highlighting the need for careful monitoring.
Ramaswamy et al. (2003) conducted a case report in Psychosis (n=4). Aripiprazole was evaluated on Exacerbation of psychosis. Initiation of aripiprazole therapy (15-30 mg daily) was associated with exacerbation of psychosis in 4 clinical cases.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: