Thalidomide (N‐phthaloylglutamimide) was used as a screening agent in the treatment of 71 patients with a wide spectrum of cancers. The production of embryonic defects by this compound prompted us to use it as an anticancer agent. There was no evidence of ob;ective response in any except one patient with renal cell cancer whose pulmonary lesions disappeared after treatment. This patient had also had nephrectomy, and it is highly possible that this response represented spontaneous regression of pulmonary metastases after operation, an event preViously observed with this tumor.
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Grabstald et al. (1965) studied this question.
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