A ribosomal beacon: The thiopeptide antibiotic thiostrepton was transformed into a fluorescent probe for the 70 S ribosomal GTPase center. Comparative affinity determinations in the pM range were achieved for thiopeptide natural products and novel semisynthetic thiostrepton antibiotics. Initial antibacterial studies of the thiostrepton derivatives against methicillin-susceptible and methicillin-resistant S. aureus (MSSA and MRSA) cell cultures are reported.
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Schoof et al. (2008) studied this question.
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