Key result
Adrenal venous sampling successfully localizes aldosterone production in a primary hyperaldosteronism patient with multiple adenomas.
Why the study?
The diagnosis and management of multiple unilateral adrenal adenomas in primary hyperaldosteronism represent a unique clinical challenge requiring precise localization of aldosterone production.
Case Report (n=1)
Adrenal venous sampling is a pivotal diagnostic tool for localizing aldosterone production in complex cases of primary hyperaldosteronism with multiple unilateral adrenal adenomas, guiding appropriate medical management.
May support AVS for localization in rare multifocal unilateral PHA; hypothesis-generating and should not yet change practice.
Primary hyperaldosteronism (PHA) is a cause of secondary hypertension, often due to adrenal adenoma. The diagnosis and management of multiple unilateral adrenal adenomas in PHA represent a unique challenge. Adrenal venous sampling (AVS) has become a pivotal diagnostic tool in these cases, providing critical information for accurate localization of aldosterone production. Here, we describe a rare case of a 52-year-old female with a history of resistant essential hypertension who presented with multiple unilateral adrenal adenomas concomitant with adrenal hyperplasia in a case of primary hyperaldosteronism. The use of AVS in localization of aldosterone production was the determining factor in deciding the ultimate management of the patient, leading to successful follow-up on medical therapy with spironolactone.
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Elhaj et al. (2026) conducted a case report in Primary hyperaldosteronism (n=1). Adrenal venous sampling (AVS) was evaluated on Localization of aldosterone production. Adrenal venous sampling successfully localized aldosterone production in a patient with primary hyperaldosteronism and multiple unilateral adrenal adenomas, leading to successful medical management.
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