Key result
Cervical discogenic pain is linked to increased insular and decreased sensorimotor ALFF versus healthy controls.
Why the study?
The detailed dynamic brain functional abnormalities in cervical discogenic pain (CDP) remain unclear despite known brain functional impairments in CDP.
Are there differences in static and dynamic amplitude of low frequency fluctuations in the brain between patients with cervical discogenic pain and healthy controls?
Case-Control (n=80)
Are there differences in static and dynamic amplitude of low frequency fluctuations in the brain between patients with cervical discogenic pain and healthy controls?
Cervical discogenic pain is associated with specific static and dynamic brain functional abnormalities, particularly in regions involved in pain processing and modulation.
Answers are grounded in this paper and cite their sources.
Identified dynamic brain changes in CDP remain hypothesis-generating; larger longitudinal studies needed before clinical relevance.
Cervical discogenic pain (CDP) is a clinically common pain syndrome caused by cervical disk degeneration. A large number of studies have reported that CDP results in brain functional impairments. However, the detailed dynamic brain functional abnormalities in CDP are still unclear. In this study, using resting-state functional magnetic resonance imaging, we explored the neural basis of CDP with 40 CDP patients and 40 age-, gender-matched healthy controls to delineate the changes of the voxel-level static and dynamic amplitude of low frequency fluctuations (ALFF). We found increased static ALFF in left insula (INS) and posterior precuneus (PCu), and decreased static ALFF in left precentral/postcentral gyrus (PreCG/PoCG), thalamus (THA), and subgenual anterior cingulate cortex in CPD patients compared to healthy controls. We also found decreased dynamic ALFF in left PreCG/PoCG, right posterior middle temporal gyrus, and bilateral THA. Moreover, we found that static ALFF in left PreCG/PoCG and dynamic ALFF in THA were significantly negatively correlated with visual analog scale and disease duration, respectively. Our findings provide the neurophysiological basis for CDP and facilitate understanding the neuropathology of CDP.
No takes yet. Share an insight, caveat, or question.
Ma et al. (2020) conducted a case-control in Cervical discogenic pain (n=80). Cervical discogenic pain vs. Healthy controls was evaluated on Static and dynamic amplitude of low-frequency fluctuations (ALFF) (p=<0.05). Cervical discogenic pain was associated with increased static ALFF in the left insula and posterior precuneus, and decreased static and dynamic ALFF in sensorimotor networks compared to healthy controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: