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Background: Parkinson’s disease (PD) is a debitlitating, chronic, progressive neurodegenerative disorder without modifying therapy. Here, we aimed to evaluate the available evidence of herbal medicine (HM) formulas for patients with PD according to randomized double-blind placebo-controlled clinical trials. Methods: HM formulas for PD were searched in eight main databases from their inception to February 2018. The methodological quality was assessed using Cochrane Collaboration risk of bias tool. Meta-analysis was performed using RevMan 5.3 software. Results: Fourteen trials with 17 comparisons comprising 1,311 patients were identified. Compared with placebo groups, HM paratherapy (n=16 comparisons) showed significant better effects in the assessments of total Unified Parkinson’s Disease Rating Scale (UPDRS) (WMD: -5.43, 95% CI:-8.01 to -2.86; P0.05. HM formulas paratherapy were generally safe and well tolerated for PD patients (RR: 0.41, 95% CI: 0.21 to 0.80; P=0.009).. Conclusion: The findings of present study supported the complementary use of HM paratherapy for PD patients, whereas the question on the efficacy of HM monotherapy in alleviating PD symptoms is still open.
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Shan et al. (2018) studied this question.
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