Key result
Scopolamine mitigates ovariectomy-induced osteoporosis by restoring bone microstructure via Nrf2 pathway activation.
Why the study?
The therapeutic effects of scopolamine on osteoporosis and its underlying mechanisms were not well understood.
Does scopolamine mitigate oophorectomy-induced osteoporosis in an OVX rat model?
Does scopolamine mitigate oophorectomy-induced osteoporosis in an OVX rat model?
Scopolamine mitigates oophorectomy-induced osteoporosis in a rat model by inhibiting oxidative stress via activation of the Nrf2 signaling pathway.
Scopolamine shows promise in an OVX rat model; leaves open translation to human osteoporosis therapy.
The aim of our research is to investigate the therapeutic effects of scopolamine (SCO) on osteoporosis and to explore the underlying mechanism. To study osteoporosis, we established an ovariectomy (OVX) model. The rats were divided into four groups: sham operation, OVX, OVX+SCO, and OVX+SCO+ML385 (Nrf2 inhibitor). ELISA, Realtime PCR, Western blot, and kits were utilised to assess the expression of related proteins and substances. The OVX rats exhibited significant weight gain, reduced bone volume, destruction of trabecular and cortical bone microstructure, decreased expression of ALP, OCN, OPN, COL1A1, Runx2, Nrf2 proteins, and CAT, SOD, GST, GPX levels while increased expression of TRAP protein and ROS levels. SCO was able to restore these indices in OVX rats, while ML385 blocked the effects of SCO. In conclusion, SCO inhibits oxidative stress response to exert therapeutic effects on osteoporosis by activating the Nrf2 signalling pathway.
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Dai et al. (2024) studied Osteoporosis. Scopolamine (SCO) vs. Sham operation, OVX alone, and OVX+SCO+ML385 was evaluated on Bone volume, microstructure, and expression of related proteins and oxidative stress markers. Scopolamine mitigated ovariectomy-induced osteoporosis by restoring bone microstructure and inhibiting oxidative stress through activation of the Nrf2 signalling pathway.
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