In this study, we examined the effect of doxycycline hydrochloride (DH) on the apical seal. Results indicated that teeth that were retrofilled with IRM or amalgam following doxycycline irrigation had significantly less dye penetration (p < 0.05). Due to its antimicrobial activity, smear layer removal ability, and improvement of apical seal, doxycycline solution may be used as an irrigant.
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Barkhordar et al. (1998) studied this question.
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