Key result
Recurrent major depressive disorder is linked to lower 10-year health-related quality of life versus controls.
Why the study?
Few studies have followed patients with recurrent major depressive disorder longitudinally to assess health-related quality of life, especially in the remitted state.
Does recurrent major depressive disorder affect long-term health-related quality of life compared to healthy controls?
Cohort
Does recurrent major depressive disorder affect long-term health-related quality of life compared to healthy controls?
Patients with recurrent major depressive disorder experience persistently lower health-related quality of life compared to healthy controls even after 10 years, despite improvements from the acute phase.
May warrant long-term HRQoL monitoring in recurrent MDD; extends short-term data yet leaves causal pathways and interventions open.
BACKGROUND: Major depressive disorder strongly affects health-related quality of life (HRQOL). Few studies have followed patients suffering recurrent major depressive disorder (rMDD) and paid attention to HRQOL in remitted state. AIM: The aim of the present study was to assess HRQOL in a 10-year longitudinal perspective in patients suffering rMDD, and comparable healthy control subjects. RESULTS: The results show significant lowered HRQOL in depressed patients on all measured domains in the acute phase of illness. CONCLUSIONS: Although HRQOL in the depressed patient group significantly improved on most measures between the two assessments, the patient group still reported a significant lowered HRQOL compared with matched controls at the 10-year follow-up assessment. More research should focus on HRQOL after a depressive episode.
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Årdal et al. (2012) conducted a cohort in Recurrent major depressive disorder. Recurrent major depressive disorder vs. Healthy control subjects was evaluated on Health-related quality of life (HRQOL). Recurrent major depressive disorder was associated with significantly lower health-related quality of life compared to matched healthy controls at 10-year follow-up.
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