The effects of daily administration of LHRH analogue (D-Ala8-desGly10) LHRH ethylamide in NaCl or propylene glycol for five days was studied on spermiation, plasma gonadotropin and 11-ketotestosterone levels. Daily injection of 10 μg/kg body weight of LHRH analogue in 0.7% NaCl increased the volume of collectable milt, the number of spermatozoa, and serum gonadotropin and 11-ketotestosterone levels. Daily injection of 1 μg/kg in NaCl or 1 μg/kg and 10 μg/kg in propylene glycol did not stimulate these respnses. Theses results indicate that LHRH analogue can stimulate the secretion of GtH from pituitary gland which in turn stimulates androgen secretion and the spermiation in the testis.
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Takashima et al. (1984) studied this question.
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