Key result
Myosin SAH domains form monomers rather than dimeric coiled coils, suggesting distinct molecular motor roles.
Why the study?
Differences between SAH domains and coiled coils in cytoskeletal molecular motors and their potential roles remain to be clarified.
Population
Cytoskeletal molecular motors including myosins, kinesins, and dyneins
Comparison
SAH domains versus coiled coils in molecular motors
Design
Review article
Authors
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Hypothesis-generating for cardiac myosin mechanics; leaves open the in vivo impact of monomeric states on contractility.
Clarifies the structural differences between SAH domains and coiled coils in cytoskeletal molecular motors, highlighting that certain myosins are monomeric.
Michelle Peckham (2011) reported a review. SAH domains in some myosins differ from coiled coils, rendering them monomeric rather than dimeric, with potential distinct roles in molecular motors.