Key result
Acute PE is linked to higher D-dimer and altered CK and CK-MB levels versus NSTEMI.
Why the study?
The value of ECGs and serological examinations in differentiating acute pulmonary embolism from acute non-ST elevation myocardial infarction to reduce clinical misdiagnosis was unclear.
Can electrocardiograms and serological examinations differentiate between acute pulmonary embolism and acute non-ST elevation myocardial infarction?
Cohort (n=140)
No
Can electrocardiograms and serological examinations differentiate between acute pulmonary embolism and acute non-ST elevation myocardial infarction?
D-dimer levels and specific cardiac enzymes can assist in the differential diagnosis of acute pulmonary embolism and NSTEMI in patients presenting with similar symptoms.
May support D-dimer and enzyme differences for differentiating PE from NSTEMI; leaves open prospective validation before clinical use.
BACKGROUND: The aim of this study was to investigate the value of electrocardiograms (ECGs) and serological examinations in the differential diagnosis of acute pulmonary embolism (APE) and acute non-ST elevation myocardial infarction (NSTEMI) in order to reduce the rate of clinical misdiagnosis. METHODS: The clinical data of 37 patients with APE and 103 patients with NSTEMI admitted to our hospital were retrospectively analyzed. The differences in the clinical manifestations, ECGs, myocardial zymograms, D-dimers, and troponin (cTn) of the two groups were compared. RESULTS: in the group of patients with APE were higher than in the group of patients with NSTEMI, and the difference was statistically significant (p < .05). There was no statistical significance in the difference of aspartate aminotransferase and lactate dehydrogenase (LDH) in the two groups (p > .05), although there was a statistically significant difference of creatine kinase (CK) and the creatine kinase isoenzyme-MB (CK-MB) in the two groups (p < .05). The levels of D-dimers and cTn were increased in both groups, but the level of D-dimers in the group of patients with APE was higher than that in the group of patients with NSTEMI. CONCLUSION: With the occurrence of clinical manifestations like dyspnea, chest tightness, chest pain, and palpitation of unknown causes, the possibility of APE and NSTEMI should be considered.
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He et al. (2021) conducted a cohort in Acute pulmonary embolism and acute non-ST elevation myocardial infarction (n=140). Acute pulmonary embolism vs. Acute non-ST elevation myocardial infarction was evaluated on Differences in clinical manifestations, ECGs, myocardial zymograms, D-dimers, and troponin (p=< .05). Acute pulmonary embolism was associated with significantly higher D-dimer levels and significant differences in CK and CK-MB compared to acute non-ST elevation myocardial infarction (p<0.05).
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