Key result
Tetrodotoxin cuts migration and invasion of metastatic ovarian cancer cells by ~55% without affecting proliferation.
Why the study?
Voltage-gated sodium channels play important roles in the development and progression of many cancers, but their roles in human ovarian cancer were not well defined.
Population
Human ovarian cancer cells including highly metastatic Caov-3 and SKOV-3, low-metastatic Anglne, and normal ovarian tissues
Comparison
30 microM tetrodotoxin treatment vs no treatment on cancer cell migration and invasion
Design
Preclinical molecular and functional study using RT-PCR, Western blot, and immunohistochemistry
Authors
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Hypothesis-generating for Nav1.5 as an antimetastatic target in ovarian cancer; prospective studies needed before clinical consideration.
Effect estimate: 50-60% reduction
Abnormal expression of Nav1.5 may be an integral component of the metastatic process in human ovarian cancer and a potential therapeutic target.
Guosheng Wang (2010) studied Ovarian cancer (n=57). Tetrodotoxin (TTX) vs. Control (0 μM TTX) was evaluated on Cell migration and invasion (50-60% reduction). Treatment with 30 μM tetrodotoxin reduced the migration and invasion of highly metastatic ovarian cancer cells by 50-60% without affecting proliferation.
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