Key result
Preoperative doxazosin linked to fewer intraoperative BP fluctuations from catecholamine surges in a pheochromocytoma case.
Why the study?
The mechanisms underlying rapid cyclic blood pressure fluctuations in patients with pheochromocytoma were not well characterized.
Does doxazosin reduce periodic blood pressure fluctuations during surgery in a patient with pheochromocytoma?
Case Report (n=1)
No
Does doxazosin reduce periodic blood pressure fluctuations during surgery in a patient with pheochromocytoma?
Alpha blockers like doxazosin may effectively reduce cyclic blood pressure fluctuations caused by catecholamine surges during surgery in patients with pheochromocytoma.
Preoperative doxazosin may attenuate catecholamine-linked BP fluctuations in pheochromocytoma surgery; single-case observation leaves open need for controlled trials.
BACKGROUND: We measured catecholamine levels during periodic blood pressure fluctuations in patients with pheochromocytoma. CASE PRESENTATION: A 43-year-old man presented with periodic blood pressure fluctuations during surgery for a renal pelvic tumor. His blood levels of catecholamines (ng/mL) changed dramatically over a short time during blood pressure fluctuations: adrenaline 0.36 to 3.22, noradrenaline 0.47 to 1.98, and dopamine 0.02. After the diagnosis of pheochromocytoma, oral treatment with doxazosin 2 mg/day was administered, and left adrenalectomy was performed 4 months after the initial surgery. Periodic circulation fluctuations occurred after tracheal intubation at the time of anesthesia induction, but the degree of fluctuation was smaller than that of the first surgery. CONCLUSIONS: The data suggest that the periodic blood pressure fluctuations in pheochromocytoma patients are caused by changes in blood catecholamine levels. Our data suggests that alpha blockers may also be effective against the cyclic fluctuations that occur in patients with pheochromocytoma.
No takes yet. Share an insight, caveat, or question.
Watanabe et al. (2022) conducted a case report in Pheochromocytoma (n=1). Doxazosin was evaluated on Blood pressure fluctuations and catecholamine levels. In a patient with pheochromocytoma, periodic blood pressure fluctuations during surgery were associated with dramatic changes in blood catecholamine levels, and preoperative doxazosin reduced the degree of these fluctuations during a subsequent surgery.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: