Key result
Aspirin and ticlopidine reduce major events in high-risk patients, but aspirin fails in healthy men.
Why the study?
The efficacy of aspirin and ticlopidine in preventing stroke and other vascular events has been extensively evaluated but requires synthesis of evidence across populations.
Does antiplatelet therapy (aspirin and ticlopidine) reduce the risk of stroke and other vascular events in patients at risk for cerebrovascular disease?
Does antiplatelet therapy (aspirin and ticlopidine) reduce the risk of stroke and other vascular events in patients at risk for cerebrovascular disease?
Aspirin and ticlopidine are effective antiplatelet agents for the prevention of stroke, myocardial infarction, and vascular death in various at-risk populations.
Aspirin may lower MI risk in high-risk men; leaves open ticlopidine's comparative benefit for stroke prevention in women.
Aspirin and the new agent ticlopidine have been the most thoroughly evaluated of the platelet-antiaggregating drugs used for the prevention of stroke and other vascular events. Numerous trials have shown aspirin to be effective in reducing the risk of myocardial infarction (MI), recurrent transient ischemic attacks, stroke, and vascular death in men at high risk for these events. Primary prevention trials have shown that aspirin reduces the risk of MI in healthy men over 50 years of age but does not reduce the risk of stroke. Two large, multicenter trials have shown that ticlopidine is effective in reducing the risk of fatal and nonfatal stroke in both men and women. Ticlopidine may also be effective in reducing the risk of recurrent stroke in patients who have had a completed thromboembolic stroke.
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J.R. Couch (1993) conducted a review in Cerebrovascular disease. Antiplatelet therapy (aspirin and ticlopidine) was evaluated. Aspirin and ticlopidine effectively reduce the risk of stroke, myocardial infarction, and vascular death in high-risk patients, though aspirin does not reduce stroke risk in healthy men.
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