MULTIPLE sclerosis, according to Grinker,1ranks third in frequency among neurologic disorders. Its incidence varies somewhat with geographic location, and apparently with other factors, for Wilson2stated that between 1908 and 1925 at the National Hospital it actually ranked first (multiple sclerosis, 1,398 cases; intracranial tumor, 1,352 cases; neurosyphilis, 1,340 cases), while the average occurrence in England and Wales over a long period was second only to that of neurosyphilis. In Switzerland2the disease is said to be twice as frequent as in England. Neilsen3stated that the disease has become much more frequent in the United States in the past fifteen years. Camp4has seen approximately 2,500 clinic cases and 700 private cases in the past forty years. In the University of Michigan Hospital the diagnosis of multiple sclerosis was made in 485 cases in the five year period ending March 31, 1947.
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Mark Zeifert (1948) studied this question.
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