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July 7, 2010Angewandte Chemie

Glycosidase Inhibition with Fullerene Iminosugar Balls: A Dramatic Multivalent Effect

Philippe Compain Camille Decroocq Julien Iehl Michel Holler Damien Hazelard Teresa Mena Barragán Carmen Ortiz Mellet Jean‐François Nierengarten

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Abstract

Superball! Ein dodekavalentes Iminozucker-Derivat mit einem Fulleren-Kern (siehe Bild) zeigt in Versuchen zur Glycosidase-Inhibition eine um bis zu drei Größenordnungen bessere Bindung als der entsprechende monovalente Ligand. Dies ist der erste Beleg für einen signifikanten Multivalenzeffekt bei der Glycosidase-Inhibition.

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Cite This Study

Compain et al. (2010) studied this question.

synapsesocial.com/papers/6aaf52621d5e7874df350139 https://doi.org/10.1002/ange.201002802

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Regiochemistry of Multiple Additions to the Fullerene Core: Synthesis of a Th-Symmetric Hexakis adduct of C60 with Bis(ethoxycarbonyl)methyleneOriginal Research · 1994 · 329 citations
2C60 Hexakisadducts with an Octahedral Addition Pattern − A New Structure Motif in Organic ChemistryOriginal Research · 2001 · 143 citations
3Efficient cyclopropanation of C60 starting from malonatesOriginal Research · 1997 · 289 citations
4Simple Modification in Hexakis-Addition for Efficient Synthesis of C60-Centered Dendritic Molecules Bearing Multiple Aromatic ChromophoresOriginal Research · 2005 · 40 citations
5Click chemistry for the efficient preparation of functionalized [60]fullerene hexakis-adductsOriginal Research · 2008 · 109 citations

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Di‐ and Dodeca‐Mitsunobu Reactions on C60 Derivatives: Post‐Functionalization of Fullerene Mono‐ and Hexakis‐Adducts2009
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