Key result
AF in patients with CAD is linked to a ~100% higher mortality risk.
Why the study?
Estimates of the prevalence of atrial fibrillation in patients with coronary artery disease have varied widely, necessitating clarification of its prevalence and clinical significance.
Cohort (n=18,343)
Answers are grounded in this paper and cite their sources.
AF signals higher mortality risk in CAD; hypothesis-generating and requires prospective validation before guiding care.
Estimates of the prevalence of atrial fibrillation (AF) in patients with coronary artery disease have varied from "frequent" to less than 2%. Data on 18,343 patients with angiographically demonstrated CAD in the Coronary Artery Surgery Study (CASS) registry were reviewed and AF was found to be present in 116 (0.6%) patients. The presence of AF was positively associated with the following clinical and angiographic variables: older age, sex (male), mitral regurgitation and functional impairment due to congestive heart failure. The number of diseased coronary arteries was negatively related to the presence of AF. Atrial fibrillation was an independent predictor of survival and its presence doubled the estimated risk over those patients without AF.
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Cameron et al. (1988) conducted a cohort in Coronary artery disease (n=18,343). Atrial fibrillation vs. Patients without atrial fibrillation was evaluated on Survival. Atrial fibrillation was present in 0.6% of patients with angiographically demonstrated CAD and independently doubled the estimated risk of mortality compared to patients without AF.
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