The retention behavior of bifonazole, clotrimazole, fenticonazole, fluconazole, ketoconazole, miconazole, metronidazole, and itraconazole, widely used antimycotic drugs have been determined by TLC by use of the binary mobile phases acetone- n -hexane, methanol-toluene, and methyl ethyl ketone-toluene containing different amounts of organic modifier. Hydrophobicity was established from the linear relationships between the solute RM values and the concentration of organic modifier. Calculated values of RM0 and C0 were considered for application in QSAR studies of the antimycotics.
No takes yet. Share an insight, caveat, or question.
Aleksić et al. (2002) studied this question.
Synapse has enriched one closely related paper. Consider it for comparative context: