Key result
Carprofen shows the greatest canine COX2 selectivity among tested NSAIDs with ~100-fold higher potency versus COX1.
Why the study?
The activity and selectivity of carprofen and other NSAIDs against canine COX1 and COX2 isozymes needed evaluation.
Population
Constitutive COX1 from washed canine platelets and COX2 from endotoxin-induced canine macrophage-like cell line
Comparison
Carprofen and other NSAIDs compared for COX1 and COX2 inhibition
Design
In vitro enzymatic activity assay with dose-response and IC50 calculations
Authors
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Carprofen's canine COX2 selectivity is hypothesis-generating; in vitro findings leave clinical translation and NSAID selection open.
Carprofen is a highly selective inhibitor of canine COX2 in vitro, which may be an important factor for its clinical use in dogs.
Ricketts et al. (1998) studied this question. Carprofen vs. Other NSAIDs was evaluated on Inhibition of canine COX1 and COX2 (IC50). Carprofen demonstrated the greatest selectivity for canine COX2 among tested NSAIDs, with a potency for COX2 more than 100-fold greater than for COX1 (IC50 0.102 microM for COX2).
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