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January 1, 2014Frontiers in NeuroscienceOpen Access

Orexin-1 and orexin-2 receptor antagonists reduce ethanol self-administration in high-drinking rodent models

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Authors

RARachel I. AndersonHBHoward C. BeckerBABenjamin L. Adams

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Anderson et al. (2014) studied this question.

synapsesocial.com/papers/6aaf5740dc4bef2ee7d0670bhttps://doi.org/10.3389/fnins.2014.00033
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Orexigenic Peptides and Alcohol Intake: Differential Effects of Orexin, Galanin, and Ghrelin2007 · 148 citations
  2. 2The Dual Orexin/Hypocretin Receptor Antagonist, Almorexant, in the Ventral Tegmental Area Attenuates Ethanol Self-Administration2012 · 75 citations
  3. 3SB‐334867‐A: the first selective orexin‐1 receptor antagonist2001 · 315 citations
  4. 4LSN2424100: a novel, potent orexin-2 receptor antagonist with selectivity over orexin-1 receptors and activity in an animal model predictive of antidepressant-like efficacy2014 · 35 citations
  5. 5Differential Effects of Acute and Chronic Ethanol Exposure on Orexin Expression in the Perifornical Lateral Hypothalamus2010 · 81 citations