Multidimensional intratumour heterogeneity in neuroblastoma

Neuroblastoma (NB) is a solid childhood cancer originating from the sympathetic nervous system.Most NBs arise from the adrenal gland but metastases to distant sites such as bone marrow, liver and lungs are not uncommon.Despite intense treatment, including highdose chemotherapy, many high-risk NBs relapse and treatment resistance is a significant clinical problem.NB is a heterogeneous disease, i.e., tumours display high inter-tumour heterogeneity.Recent findings also point to genetic intratumour heterogeneity (ITH) in NB, albeit www.oncotarget.com