Why the study?
Does shifting one antihypertensive medication to the evening improve the night-to-day ambulatory blood pressure ratio in CKD patients with a nondipper blood pressure profile?
Does shifting one antihypertensive medication to the evening improve the night-to-day ambulatory blood pressure ratio in CKD patients with a nondipper blood pressure profile?
Shifting one antihypertensive medication to the evening in CKD patients with a nondipper profile restores the normal circadian blood pressure rhythm and reduces proteinuria.
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Bloch et al. (2008) studied Chronic kidney disease with nondipper hypertension (n=32). Shifting one antihypertensive medication from morning to evening was evaluated on Percentage of patients changing the night to day (N/D) ratio of mean ABPM from >0.9 to ≤0.9.
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