Key result
Cognitive dysfunction affects 34% of peritoneal dialysis patients, linked to age, gender, and clinical predictors.
Why the study?
Cognitive disorders significantly impact quality of life, mortality, hospitalizations, healthcare burden, and costs in patients undergoing peritoneal dialysis, but prevalence and risk factors are not well defined.
Cross-Sectional (n=30)
No
In patients undergoing peritoneal dialysis, cognitive dysfunction is highly prevalent (34%) and is significantly associated with female gender, older age, higher glucose levels, and dialysis adequacy.
Cognitive screening may warrant consideration in PD patients, especially females and those ≥60; leaves open whether it improves outcomes.
Objective. Cognitive disorders are a global health problem, as they deteriorate patients' quality of life, increase mortality and the number of hospitalizations, burden the healthcare system, and raise treatment costs. The aim of this research is to determine the prevalence of cognitive dysfunction in patients undergoing peritoneal dialysis. Methods. A cross-sectional study was conducted in May 2024, at the Clinic of Nephrology and Clinical Immunology Clinical center of Vojvodina, University of Novi Sad. . The study included 30 patients undergoing peritoneal dialysis. The Montreal Cognitive Assessment (MoCA) was used as the instrument for assessing cognitive dysfunction. Results. Of the 30 patients, 55.2% were male. The most represented age category was ≥60 years, comprising 43.5%. Among comorbidities, hypertension was the most prevalent at 33.3%. Cognitive dysfunction was confirmed in 34% of the patients. A logistic regression model was applied to identify predictors of cognitive dysfunction, revealing that female patients and those over 60 years of age were at a higher risk for cognitive dysfunction. A positive correlation between the MMSE score and the total dialysis adequacy index Kt/V was also identified. Conclusion. Significant predictors of cognitive dysfunction in patients on peritoneal dialysis were: female gender, age category (above 60 years), glucose levels, daily and weekly doses of vitamin D, and the dialysis adequacy index Kt/V.
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Novković-Joldić et al. (2024) conducted a cross-sectional in End-stage renal disease on peritoneal dialysis (n=30). Risk factors (age, gender, glucose, vitamin D, Kt/V) vs. Absence of risk factors was evaluated on Cognitive dysfunction (score < 25). Cognitive dysfunction was present in 34% of patients on peritoneal dialysis, with female gender, age over 60, glucose levels, vitamin D dose, and Kt/V identified as significant predictors.
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