Key result
Novel wild boar HEV isolate shares less than ~75% nucleotide identity, representing proposed genotype 5.
Why the study?
A hepatitis E virus isolate from a wild boar showed low nucleotide identity to known HEV genotypes 1 through 4 and rabbit HEV isolates, suggesting a potentially new genotype.
A peculiar nucleotide sequence of HEV RNA was recovered from a wild boar (Sus scrofa leucomystax ) of male sex with about 10 kg of body weight, captured 1-Feb-2009 in the forest of Tenryu-ku, Hamamatsu, Shizuoka, Japan. The sequence (JBOAR135-Shiz09, accession number AB573435) showed only less than 80% nucleotide identity to so far reported sequences of HEV genotype 1 through 4 (72.7-76.4% vs G1, 75.5% vs G2, 71.2-78.2% vs G3, 74.9-78.2% vs G4) and also to the rabbit HEV isolates recently reported from China (75.5-77.3%). Since the rabbit HEV segregates to genotype 3 in the present phylogenetic analysis (CLUSTALW Unrooted N-J Tree Method), we propose our JBOAR135-Shiz09 isolate as the first member of new genetic group of HEV, "genotype 5".
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Takahashi et al. (2010) studied Hepatitis E virus (HEV) (n=1). Phylogenetic analysis of HEV RNA vs. Known HEV genotypes 1-4 and rabbit HEV was evaluated on Nucleotide identity of HEV RNA sequence. A novel hepatitis E virus isolate recovered from a wild boar in Japan showed less than 75% nucleotide identity to known genotypes 1-4, representing a proposed new genotype 5.
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