Immune profile of a patient with Parkinson’s disease and autoimmune disease. A case report

While several studies have been conducted on the immune cell populations in systemic lupus erythematosus (SLE) and Parkinson's disease (PD) patients, very few works have focused on the relationship between both diseases.Being a purely autoimmune disease, SLE is known to exhibit high levels of proinflammatory cells.On the other hand, neuroinflammation is a key contributor to the death of dopaminergic neurons in PD.Herein, we report the case of a patient suffering from both SLE and PD, comparing it with a patient suffering from PD only.Our results are informative, showing decreased levels of regulatory populations like CD8+regs and functional Bregs in the SLE/PD patient.In contrast, the levels of tolerogenic dendritic cells were up to 10 times higher in this patient.Additionally, the levels of Tr1, Th3, and functional CD8 cells, as well as those of M2-like monocytes, were higher in the SLE/PD patient.Regarding the inflammatory response, increased levels of total CD8+ T cells and CD40-expressing DCs were observed.In conclusion, significant changes in the levels of immune cell populations were observed in a patient suffering from SLE and PD, suggesting that the immune response could impact the pathophysiology of PD.