Analytical techniques for determination of metformin-thiazolidinediones combination antidiabetic drug

InformationDiabetes mellitus (DM) remains a significant global health challenge, causing considerable mortality and morbidity annually.Type 2 DM is the most prevalent form of the disease, and fixed-dose combinations of oral anti-diabetic drugs are essential for its management.Their use creates a substantial demand for analytical methods capable of handling the diverse matrices, compounds, and physicochemical complexities involved in the quantitative analysis of these drug combinations.This article reviews current analytical methods for quantitatively determining metformin combined with thiazolidinediones in various marketed formulations.The review covered the period from 2005 to the present.The most commonly used methods include high-performance liquid chromatography (HPLC), spectrophotometric techniques, high-performance thin-layer chromatography (HPTLC), and capillary zone electrophoresis (CZE).Recent trends indicate a preference for HPLC (44.8%) due to its higher sensitivity, resolution potential, reduced sample and reagent consumption, and shorter analysis times.This shift underscores the industry's move towards more efficient and precise analytical techniques.