Key result
Carotid plaque is linked to larger sinus diameter, junction angle, and CS/CCA ratio.
Why the study?
Plaque formation in atherosclerosis preferentially occurs at specific vascular branch sites, but factors causing plaque formation in only one carotid sinus remain unclear.
Are vessel diameter and junction angle associated with unilateral plaque formation in the carotid sinus?
Cross-Sectional (n=100)
No
Are vessel diameter and junction angle associated with unilateral plaque formation in the carotid sinus?
Larger vessel diameter and junction angle in the carotid sinus are associated with unilateral plaque formation, likely due to altered shear stress.
Larger carotid sinus diameter and angle associate with unilateral plaque; hypothesis-generating for local geometry in atherogenesis, needs prospective confirmation.
目的：粥状動脈硬化病変（Plaque）は，比較的大きな血管の分枝部など特定部位に好発する特性がある．しかし，左右頸動脈洞（CS）の一方のみにPlaque形成を認めることは，臨床現場にてしばしば遭遇する．我々は，血管径などが一方のみにPlaqueを形成させている要因と推測し，それらの因子がPlaque形成に与える影響について研究した．対象と方法：2009年4月から2010年3月までに医療法人生登会寺元記念西天満クリニックにて頸動脈超音波検査を実施した外来患者の内，左右一方のCSのみにPlaque形成を認めた100例（男性68人，女性32人）を対象とした．頸動脈超音波検査にて，左右両側の総頸動脈（CCA）とCSの接合角，各血管径，血管径比（CS/CCA），平均内膜中膜複合体厚及び流速を求めた．Plaque形成を認めた側をP側，認めない側をN側として，各因子を比較検討した．結果と考察：接合角，CS径とCS/CCAは，P側の方がN側に比較して有意に高値を示した．本研究結果より，血管径や接合角は血管内皮へかかるずり応力に影響し，Plaque形成の重要な因子になると推測された．結論：血管径や接合角がPlaque形成の要因であることが示唆された．
No takes yet. Share an insight, caveat, or question.
Michikura et al. (2011) conducted a cross-sectional in Unilateral carotid sinus plaque (n=100). Plaque formation side (P side) vs. Non-plaque side (N side) was evaluated on Junction angle, CS diameter, and CS/CCA ratio. Carotid sinus diameter, junction angle, and the CS/CCA ratio were significantly higher on the side with plaque formation compared to the side without plaque.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: