Key result
A positive MRZ reaction (MRZR-1) was found in 83.5% of patients with primary progressive multiple sclerosis compared to 67.8% of those with relapsing-remitting multiple sclerosis.
Why the study?
It was uncertain whether the differential diagnostic promise of the MRZ reaction extends to patients with primary-progressive multiple sclerosis (PPMS).
Does the MRZ reaction help distinguish primary progressive multiple sclerosis from other inflammatory neurological diseases?
Cross-Sectional (n=251)
No
Does the MRZ reaction help distinguish primary progressive multiple sclerosis from other inflammatory neurological diseases?
The MRZ reaction is highly prevalent in primary progressive multiple sclerosis, confirming its utility as a diagnostic tool to distinguish MS from other inflammatory neurological diseases.
May support MRZ reaction differences across MS phenotypes; leaves open its diagnostic value versus other inflammatory neurological diseases.
BACKGROUND: The MRZ reaction (MRZR), composed of the three antibody indices (AI) against measles, rubella and varicella zoster virus and found positive in the majority of relapsing-remitting multiple sclerosis (RRMS) patients, is absent in other inflammatory neurological diseases (OIND). So far, it has been uncertain whether its differential diagnostic promise extends to patients with primary-progressive multiple sclerosis (PPMS). OBJECTIVE: To investigate the prevalence of MRZR in PPMS compared to RRMS and OIND patients. METHODS: MRZR was assessed in patients with PPMS (n = 103), RRMS (n = 100) and OIND (n = 48). Both stringency levels for MRZR testing, MRZR-1 (≥1 AI positive) and MRZR-2 (≥2 AI positive), were applied. RESULTS: Prevalence of positive MRZR-1 was 83.5% in PPMS and 67.8% in RRMS (p < 0.05). A positive MRZR-2 was found in 54.4% of PPMS and in 43.0% of RRMS patients (not significant). Compared to both MS subgroups, OIND patients exhibit lower frequencies of positive MRZR (MRZR-1: 22.9%, MRZR-2: 8.3%; p < 0.0001 each). CONCLUSION: Positive MRZR was at least as frequent in PPMS as in RRMS and much less frequent in OIND, confirming its promise as a potentially useful diagnostic tool for distinguishing both MS course types from OIND.
No takes yet. Share an insight, caveat, or question.
Hottenrott et al. (2017) conducted a cross-sectional in Primary progressive multiple sclerosis (n=251). Primary progressive multiple sclerosis (PPMS) vs. Relapsing-remitting multiple sclerosis (RRMS) was evaluated on Prevalence of positive MRZR-1 (≥1 antibody index positive) (p=<0.05). A positive MRZ reaction (MRZR-1) was found in 83.5% of patients with primary progressive multiple sclerosis compared to 67.8% of those with relapsing-remitting multiple sclerosis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: