Key result
Human ECEL1 gene localizes to chromosome 2 and shares structural similarities with related metallopeptidases.
Why the study?
The physiological function and chromosomal localization of the human ECEL1 gene, a zinc metalloprotease involved in nervous control of respiration, were unknown.
Design
Gene characterization and phylogenetic study
Authors
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Human ECEL1 mapping enables genetic studies of respiratory control; leaves open any cardiorespiratory role in patients.
Valdenaire et al. (2000) studied this question. The human ECEL1 gene, composed of 18 exons spanning approximately 8 kb, was localized to chromosome 2 region q36-q37 and shares structural similarities with related metallopeptidases.
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