Surface enhanced Raman scattering (SERS) spectroscopy has been used to study the interfacial behaviour of DNA modified by cis-Pt(NH3)2Cl2, (cis-DDP) and [Pt-(dien)Cl]Cl bidentate and monodentate platinum coordination compounds, respectively. Two stereochemical configurations of Pt-DNA complexes can be deduced from the adsorption behaviour of the Pt adducts. The antitumoral inactive [Pt-(dien)Cl] Cl forms an outer complex whereas the antitumoral active cis-DDP favours an inner complex.
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Séquaris et al. (1984) studied this question.
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