Key result
Eating disorders are linked to ~15% higher odds of elevated AST and lower bone density.
Why the study?
Extreme weight conditions and eating disorders in young women are associated with adverse health outcomes and medical complications, but their biochemical, hematologic, and skeletal features require further investigation.
Cross-Sectional (n=808)
Yes
Eating disorders and extreme weight conditions in young Korean women are associated with distinct biochemical, hematologic, and skeletal abnormalities, largely mirroring patterns seen in Western populations.
May warrant monitoring liver enzymes, lipids, and BMD by weight status in young women with eating disorders; extends Western patterns to Korean cohorts but remains hypothesis-generating.
Background: Extreme weight conditions in young women are associated with adverse health outcomes. Closely linked with extreme weight status, eating disorders (EDs) are associated with several medical complications and high mortality rates. Objective: The study aimed to investigate the biochemical, hematologic, and skeletal features of young Korean women with underweight (UW) and overweight/obesity (OW) conditions, and patients with anorexia nervosa (AN) and bulimia nervosa (BN) compared to women with normal-weight (NW). Method: ), 63 patients with anorexia nervosa (AN), and 100 with bulimia nervosa (BN). We measured blood pressure and performed biochemical, hematologic and bone mineral density (BMD) evaluations at the lumbar and femoral neck. Results: Blood pressure and triiodothyronine levels were found to be lower in both ED groups and higher in the OW group, but no difference in the UW group, compared to the NW group. The aminotransferases and total cholesterol levels were higher in the ED and OW groups, compared to the NW group. Blood cell counts were decreased in the AN group, while increased in the OW group, compared to the NW group. Blood urea nitrogen was elevated in both ED groups. The UW and AN groups had lower BMD, whereas the OW group had higher BMD, compared to the NW group. Conclusion: Our findings suggested that both ED groups were associated with decreases in the resting energy expenditure. OW status was associated with a risk of metabolic syndrome, and UW status with lower BMD in young women. Overall, the medical parameters in Korean patients with ED were similar to the patterns reported in Western samples in previous studies, with few exceptions such as potassium level in BN.
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An et al. (2022) conducted a cross-sectional in Underweight, overweight, and eating disorders (n=808). Extreme weight conditions and eating disorders vs. Normal-weight was evaluated on Aspartate aminotransferase (AST) level (Anorexia Nervosa vs Normal-Weight) (OR 1.15, 95% CI 1.11-1.20, p=<0.001). Compared to normal-weight women, young Korean women with eating disorders and overweight status exhibited elevated aminotransferases and total cholesterol, while anorexia nervosa and underweight status were associated with lower bone mineral density.
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