Key result
Guangdong goose circoviruses show high genomic identity with known strains despite 9 diversifying recombination events.
Why the study?
Extensive genetic diversity and recombination events of goose circoviruses circulating in domesticated geese in Guangdong province were not well characterized.
Observational
Answers are grounded in this paper and cite their sources.
Extensive GoCV diversity in geese livers signals surveillance needs; leaves open links to immunosuppression and secondary infections.
Circoviruses represent a group of small viruses with circular single-strand DNA genome that infect a wide range of both domesticated and wild animals. Domesticated geese infected with circovirus have been confirmed in many parts of the world, and is considered to cause immunosuppression and facilitate the secondary infections caused by other pathogens. In the present study, extensive genetically diversified goose circoviruses (GoCVs) were identified in the liver samples of domesticated geese from Guangdong province, southern China. Genetic analysis revealed that the sequences generated in this study shared 81.5 to 99.7% genome-wide pairwise identity with previously identified GoCV genomes. More importantly, nine recombination events were identified among all known complete genomome sequences of GoCV including those obtained herein, and the majority was determined associate with the sequences identified from Guangdong province, suggesting that recombination is the primary driver for the diversification of GoCVs. Additionally, purifying selection was the dominant evolutionary pressure acting on the genomes of GoCVs, and the ORF C1 gene of GoCV showed a higher genetic variation than ORF V1 gene. These results expand the knowledge about the genetic diversity and evolution of GoCV, and also indicate extensive genetically divergent GoCV strains were co-circulating in goose population in partial areas of Guangdong province, southern China.
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Yao et al. (2022) conducted an observational in Goose circovirus infection. Goose circovirus (GoCV) genetic analysis was evaluated on Genetic diversity and recombination events. Genetic analysis of goose circoviruses from Guangdong province revealed 81.5 to 99.7% genome-wide pairwise identity with known genomes and identified nine recombination events driving diversification.
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