Key result
Higher insulin resistance links to greater carotid arterial stiffness in nondiabetic hemodialysis patients.
Why the study?
Patients with end-stage renal disease have insulin resistance and advanced arterial stiffness, but the correlation between insulin resistance and carotid arterial stiffness in hemodialysis patients was unclear.
Is insulin resistance associated with carotid arterial stiffness in nondiabetic hemodialysis patients?
Cross-Sectional (n=80)
Is insulin resistance associated with carotid arterial stiffness in nondiabetic hemodialysis patients?
Effect estimate: beta = 0.260
p-value: p=0.016
Insulin resistance is independently associated with carotid arterial stiffness in nondiabetic hemodialysis patients, highlighting a potential mechanism for cardiovascular risk in this population.
Association with carotid stiffness supports hypothesis generation; should not change practice pending prospective confirmation in hemodialysis.
BACKGROUND: Patients with end-stage renal disease are known to have insulin resistance and advanced arterial stiffness. The present study was undertaken to investigate whether insulin resistance was correlated with carotid arterial stiffness in hemodialysis patients. METHODS: Eighty nondiabetic hemodialysis patients were recruited. Stiffness index beta of the common carotid artery was assessed by ultrasound using echo-tracking system. Insulin resistance was evaluated by the homeostasis model assessment method (HOMA-IR). Serum albumin, lipid profile, calcium, phosphorus, intact parathyroid hormone, high-sensitivity C-reactive protein and oxidized low-density lipoprotein (ox-LDL) were also measured. RESULTS: Patients with higher HOMA-IR levels had higher BMI, ox-LDL, and stiffness index beta than patients with lower HOMA-IR levels. HOMA-IR was independently correlated with stiffness index beta (beta = 0.260, p = 0.016). BMI and ox-LDL were independent contributors to HOMA-IR. CONCLUSION: Insulin resistance assessed by HOMA-IR is closely associated with carotid arterial stiffness in nondiabetic hemodialysis patients.
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Zhou et al. (2009) conducted a cross-sectional in End-stage renal disease on hemodialysis (n=80). Insulin resistance (HOMA-IR) vs. Lower HOMA-IR levels was evaluated on Carotid arterial stiffness (stiffness index beta) (beta = 0.260, p=0.016). Insulin resistance assessed by HOMA-IR was independently correlated with carotid arterial stiffness index beta (beta = 0.260, p = 0.016) in nondiabetic hemodialysis patients.
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