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Experimental formulation study demonstrates stable transdermal patches with enhanced antibacterial activity against Staphylococcus aureus, suggesting a novel plant-based topical antimicrobial.
Background: Fermentation of green tea with kombucha starter can increase the content of polyphenols and catechins. Both of these secondary metabolites have activity as antibacterial and antioxidant. The transdermal patch can be applied to the skin as an antibacterial.Objective: The purpose of this study was to formulate a patch of kombucha green tea which has antibacterial activity against S. aureus.Method: The research started with the fermentation of kombucha green tea; patch formulations with kombucha variations of 10% (F1), 15% (F2), and 20% (F3); patch evaluation; and activity test using the paper disc diffusion method.Results: The results showed an increase in antibacterial activity in kombucha green tea (fermented) by 40.58%. The evaluation results of the kombucha patch, all formulas (F1, F2, and F3) have a weight and thickness that are not significantly different from the comparison (market patches), while the pH stability, all formulas show a stable pH for 28 days of storage.Conclusion: The conclusion of this study is that kombucha green tea can be formulated in the form of a patch and has potential as an antibacterial against S.aureus.Keywords: Green Tea; Kombucha; Paper Disc Diffusion; Patch; S.aureus
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Muhsinin et al. (2023) studied this question.
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