Key result
Acute pancreatitis is linked to lower plasma LPL and GPIHBP1 levels that correlate with severity.
Why the study?
The relationship between plasma LPL and GPIHBP1 levels and lipid metabolism abnormalities in patients with pancreatitis with normal triglycerides was unclear.
Are plasma LPL and GPIHBP1 levels altered in patients with pancreatitis who have normal blood triglycerides?
Observational (n=107)
No
Are plasma LPL and GPIHBP1 levels altered in patients with pancreatitis who have normal blood triglycerides?
Pancreatitis is associated with abnormal lipid metabolism, characterized by a decrease in LPL and GPIHBP1 levels that correlates with disease severity.
Reductions in LPL and GPIHBP1 associate with acute pancreatitis severity; hypothesis-generating for lipid biomarkers, prospective validation needed.
Plasma LPL and GPIHBP1 levels and other lipid metabolic factors in patients with pancreatitis with blood triglycerides in the normal range were measured over time. The subjects included patients with acute pancreatitis (AP) (n=57) and chronic pancreatitis (CP) (n=30), and 20 healthy controls. Plasma LPL and GPIHBP1 were measured by enzyme-linked immunosorbent assay, apo protein by immunoturbidimetric assay, and other lipids by routine methods. Disease status was based on the APACHE-II score at the time of blood sampling. AP cases showed a significant decrease in LPL and GPIHBP1 compared to controls, whereas CP cases showed a non-significant decrease. ApoC2 II and III levels in patients with pancreatitis were lower than those in controls. LPL and GPIHBP1 levels were significantly positively correlated with each other, and both showed a significant negative correlation with the APACHE-II score. LPL and GPIHBP1 levels in pancreatitis survivors and non-survivors showed a trend towards a decrease with worsening disease and an increase with recovery. Serum triglyceride levels showed a non-significant negative correlation with LPL and GPIHBP1 levels. These results suggest that pancreatitis is related to abnormal lipid metabolism, mainly through a decrease in LPL in the course of the disease.
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Matuyama et al. (2023) conducted an observational in Pancreatitis (Acute and Chronic) (n=107). Pancreatitis vs. Healthy controls was evaluated on Plasma LPL and GPIHBP1 levels (p=<0.05). Patients with acute pancreatitis had significantly decreased plasma LPL and GPIHBP1 levels compared to healthy controls, which negatively correlated with disease severity.
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