Key result
FGB -455 G/A polymorphism linked to elevated plasma fibrinogen in noncardioembolic ischemic stroke.
Why the study?
The relationship between the beta-fibrinogen gene -455 G/A polymorphism and plasma fibrinogen levels, and its frequency difference between LAA and SVO stroke subtypes in Korean ischemic stroke patients, was unclear.
Is the beta-fibrinogen gene -455 G/A polymorphism associated with plasma fibrinogen levels and specific noncardioembolic stroke subtypes in Korean patients?
Observational (n=267)
No
Is the beta-fibrinogen gene -455 G/A polymorphism associated with plasma fibrinogen levels and specific noncardioembolic stroke subtypes in Korean patients?
Absolute Event Rate: 297.67% vs 262.71%
p-value: p=<0.001
The FGB -455 G/A polymorphism is associated with elevated plasma fibrinogen in Korean noncardioembolic stroke patients but does not distinguish between large-artery atherosclerosis and small-vessel occlusion subtypes.
May link FGB -455 G/A to fibrinogen in Korean stroke patients; leaves open differential frequency in LAA versus SVO.
BACKGROUND AND PURPOSE: We investigated the relationship between the beta-fibrinogen gene (FGB) -455 G/A polymorphism and plasma fibrinogen levels in Korean ischemic stroke patients. We also determined whether the frequency of the -455 G/A polymorphism differed between two subtypes of noncardioembolic stroke: large-artery atherosclerosis (LAA) and small-vessel occlusion (SVO). METHODS: A total of 267 patients with noncardioembolic stroke were enrolled. Plasma fibrinogen and other risk factors for stroke were evaluated. FGB -455 G/A genotypes were determined by polymerase chain reaction with restrictive enzyme Hae III and automatic DNA sequencing. RESULTS: The FGB -455 G/A polymorphism was significantly associated with an elevated plasma fibrinogen level (p<0.001). The frequency of the A allele in Korean stroke patients was 16.7%. However, the frequency of the -455 G/A polymorphism did not differ between LAA and SVO. CONCLUSIONS: The plasma fibrinogen level might be affected by the -455 G/A polymorphism in noncardioembolic stroke patients. However, the LAA and SVO subtypes of ischemic stroke were not affected by the -455 G/A polymorphism.
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Lee et al. (2008) conducted an observational in Noncardioembolic ischemic stroke (n=267). FGB -455 G/A polymorphism vs. FGB -455 G/G genotype was evaluated on Plasma fibrinogen level (mg/dL) (p=<0.001). The FGB -455 G/A polymorphism was significantly associated with elevated plasma fibrinogen levels compared to the wild-type genotype in Korean patients with noncardioembolic ischemic stroke.
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