Sickle Cell Disorders and Severe COVID-19 Outcomes: A Cohort Study

Acknowledgment: The authors thank the EMIS (Egton Medical Information Systems) practices that contribute to the database as well as the University of Nottingham and University of Oxford for expertise in establishing, developing, and supporting the QResearch database. QResearch acknowledges funding from the Nottingham Biomedical Research Centre funded by the National Institute for Health Research. The data on SARS-CoV-2 reverse transcriptase polymerase chain reaction tests were used with permission from Public Health England. The Hospital Episode Statistics data and civil registration data used in this analysis are reused by permission from NHS Digital, which retains the copyright. This study was undertaken as part of a larger project, which is detailed at www.qresearch.org/research/approved-research-programs-and-projects/quantifying-the-association-between-covid-19-ethnicity-and-mortality-a-cohort-study-across-three-uk-national-databases. Financial Support: By grant MR/V027778/1 from the UK Medical Research Council. Dr. Clift is supported by a Clinical Research Training Fellowship from Cancer Research UK (DCS-CRUK-CRTF20-AC, C2195/A31310). Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M21-1375. Reproducible Research Statement: Study protocol: Available at www.qresearch.org/research/approved-research-programs-and-projects/quantifying-the-association-between-covid-19-ethnicity-and-mortality-a-cohort-study-across-three-uk-national-databases. Statistical code: Available on request to Dr. Clift (e-mail, ashley.clift@phc.ox.ac.uk). Code groups used by the researchers are available at www.qresearch.org/qcode-group-library. Data set: Access to the anonymized health care data in the QResearch database is on application to the QResearch Scientific Committee by bona fide researchers employed at U.K. academic institutions according to information on www.qresearch.org.