Key result
Lobectomy confirms primary pulmonary synovial sarcoma diagnosis via SYT-SSX1 gene fusion detection.
Why the study?
Primary synovial sarcoma of the lung is a rare tumor requiring detailed clinicopathologic, immunohistochemical, and molecular characterization.
Case Report (n=1)
This case report highlights the diagnosis of a rare primary pulmonary synovial sarcoma confirmed by the detection of the SYT-SSX1 gene fusion transcript.
Rare pulmonary synovial sarcoma may enter the differential for atypical lung masses; extends sparse case literature but leaves management strategies open.
We report a rare case of primary synovial sarcoma of the lung. A57-year-old man had a well-defined tumor in the right middle lobe seen on chest computed tomography, and underwent lobectomy. Grossly, the nonencapsulated tumor measured 4.5 cm in greatest diameter, with a solid and tan-white cut surface. Histologically, the tumor was mainly composed of a dense proliferation of spindle cells. Immunohistochemical studies were focally positive for epithelial membrane antigen, and diffusely positive for CD99 and Bcl-2. Cytokeratin, S-100 protein, desmin, smooth muscle act in, and CD34 were absent. SYT-SSX1 gene fusion transcript was detected by reverse transcription-polymerase chain reaction, which is diagnostic of primary synovial sarcoma of the lung. We also review the literature with regard to the clinicopathologic, immunohistochemical, and molecular studies of primary pulmonary synovial sarcoma.
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Chen et al. (2006) conducted a case report in Primary pulmonary synovial sarcoma (n=1). Lobectomy was evaluated. A 57-year-old man was diagnosed with primary pulmonary synovial sarcoma, confirmed by the detection of the SYT-SSX1 gene fusion transcript following lobectomy.
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