Pellitorine [5] ( (2E, 4E)-N-isobuty1-2, 4-decadienamide) was synthesized from 1-heptyne [6] and methyl (E)-3-bromopropenoate [8] by a palladium catalysed stereospecific alkenylalkenyl cross-coupling reaction. This is a new facile synthetic method of pellitorine [5]. Fifteen amide analogues of pellitorine [12]∼[26] were also synthesized and their insecticidal activities against adzuki bean weevil (Callosobruchus chinensis L.) were reported.