Key result
Central and ectopic fat are linked to higher postmenopausal cardiometabolic risk while peripheral fat is cardioprotective.
Why the study?
Menopause-related hormonal changes lead to increased cardiometabolic risk factors and changes in body composition, but the role of lean body mass in metabolic syndrome in postmenopausal women is less conclusive.
Central fat accumulation increases cardiometabolic risk in postmenopausal women, whereas peripheral subcutaneous fat is cardioprotective.
Menopause-related hormonal changes are associated with an increased prevalence of various cardiometabolic risk factors, components of the metabolic syndrome, and an excess risk of all-cause and cardiovascular mortality. Estrogen withdrawal and the subsequent androgenicity interact in a synergistic manner to predispose post menopausal women to an increase in total body weight but also to a pronounced change of body composition. Central fat accumulation and ectopic fat storage constitute potent determinants of the increased cardiometabolic risk in post menopausal women. In contrast, peripheral subcutaneous fat has an independent cardioprotective and anti-atherogenic impact. Data are less conclusive regarding the contribution of lean body mass to metabolic syndrome and cardiometabolic health in post menopausal women.
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Μelpomeni Peppa (2012) conducted a review in Metabolic syndrome and cardiometabolic risk. Body composition changes (central fat accumulation vs. peripheral subcutaneous fat) was evaluated. Central fat accumulation and ectopic fat storage increase cardiometabolic risk in postmenopausal women, whereas peripheral subcutaneous fat has an independent cardioprotective impact.
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