Key result
Extracellular vesicle surface characteristics like glycans and zeta potential regulate biodistribution and cellular uptake.
Why the study?
Extracellular vesicles have molecular features beyond their content that may influence their clinical applications and biological fate, which require further discussion.
This review emphasizes the role of extracellular vesicle structural features, including lipids, glycans, and electric charge, in vascular pathophysiology and potential clinical applications.
EV surface features merit attention in vascular pathophysiology research; leaves open clinical translation pending prospective data.
Extracellular vesicles (EVs) are released by all cells, both in physiological and pathological conditions. Their molecular charge and composition emerge as possible biomarkers, but EVs may also be considered for other clinical applications. This review discusses the role of other features of EVs, such as their lipid components or composition of glycans that form the EV corona and regulate EV biodistribution and uptake by target cells. The importance of EV electric charge has been discussed as a new insight into EV fate and destination.
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Stępień et al. (2023) conducted a review in Vascular pathophysiology. Extracellular vesicles was evaluated. Extracellular vesicles possess specific surface characteristics, such as glycan composition and zeta potential, which regulate their biodistribution, cellular uptake, and potential clinical applications.
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