Key result
mRNA COVID-19 vaccination linked to Takotsubo syndrome and Graves' disease in 1 patient.
Why the study?
Cardiovascular events such as myocarditis following mRNA COVID-19 vaccination are increasing, but other cardiovascular adverse events remain less described.
Case Report (n=1)
This case highlights the possibility of Takotsubo Syndrome and Graves' disease as rare cardiovascular and endocrine adverse events following mRNA COVID-19 vaccination.
Answers are grounded in this paper and cite their sources.
May signal rare post-vaccination cardiac events in susceptible patients; leaves open causality and requires larger studies before any practice change.
Cardiovascular events such as myocarditis following mRNA COVID-19 vaccination are increasing. We present a 67-year-old postmenopausal woman with Takotsubo Syndrome and Graves' disease after mRNA COVID-19 vaccination. She developed chest pain and shortness of breath one week after vaccination. An electrocardiogram revealed ST elevation in the precordial leads. Coronary angiography revealed the absence of obstructive coronary artery disease, and the left ventriculography showed a typical feature with apical ballooning. Laboratory workup showed the elevation of free T4 and thyrotropin receptor antibodies. It was presumed that Takotsubo Syndrome and Graves' disease were probably related to the COVID-19 mRNA vaccination. The patient was treated with low-dose bisoprolol, diuretics, carbimazole, and steroid and discharged uneventfully. The mRNA COVID-19 vaccination is still safe and effective to defend against COVID-19 pandemic. However, clinicians should be aware of the possible cardiovascular adverse events other than myocarditis following vaccination.
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Chen et al. (2022) conducted a case report in Takotsubo Syndrome and Graves' disease (n=1). mRNA COVID-19 vaccination was evaluated on Development of Takotsubo Syndrome and Graves' disease. mRNA COVID-19 vaccination was followed by the development of Takotsubo Syndrome and Graves' disease in 1 patient, who was successfully treated and discharged.
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