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A versatile method to selectively encapsulate water-insoluble molecules in the nanoshell of layer-by-layer capsules made exclusively of polysaccharides is described. This relies on the very high affinity of hydrophobic molecules for an alkylated hyaluronic acid used as a polyanionic partner of a chitosan derivative for the capsule synthesis. The hydrophobic molecules entrapped in the nanoshell can be delivered intracellularly in dendritic cells.
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Cui et al. (2011) studied this question.
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