Investigation of RNA–Ligand Interactions by 19F NMR Spectroscopy Using Fluorinated Probes

This is the authors' abstract. We don't add key points for this paper.

Spy swap: The interaction between an unlabeled RNA and unlabeled ligands (red hexagon) can be monitored by 19F NMR spectroscopy using small fluorinated diamines (green star) as spy reporters (see scheme). This technique also enables the visualization of the conformational capture of a riboswitch by its ligand.