Key result
IV sulphinpyrazone lowers HR by ~15 beats/min and delays VF during coronary occlusion in dogs.
Why the study?
The effects of sulphinpyrazone on heart rate, blood pressure, and ventricular arrhythmias during acute myocardial ischaemia were studied to understand its protective mechanisms.
Does sulphinpyrazone improve haemodynamics and reduce ventricular arrhythmias in experimental myocardial ischaemia?
Does sulphinpyrazone improve haemodynamics and reduce ventricular arrhythmias in experimental myocardial ischaemia?
Sulphinpyrazone protects against early ventricular fibrillation during acute experimental myocardial ischaemia, an effect that may be mediated by heart rate reduction.
Suggests anti-VF potential for sulphinpyrazone in animal ischaemia; leaves open clinical translation and human efficacy.
The effect of sulphinpyrazone (30 mg/kg i.v.) on heart rate, blood pressure and ventricular arrhythmias was studied in open-chested anaesthetized dogs during sequential 10 min occlusions of the left anterior descending coronary artery. An increased duration of occlusion without ventricular fibrillation and reduction in epicardial activation delay in the central ischaemic region were observed after intravenous sulphinpyrazone (n = 7). These effects were associated with a progressive and significant reduction in intrinsic heart rate (up to 15 beats/min) but no change in blood pressure. These findings suggest that heart rate changes alone may account for the observed protective effect of sulphinpyrazone against early ventricular fibrillation during acute experimental myocardial ischaemia.
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Douglas C. Russell (1981) studied Experimental myocardial ischaemia (n=7). Sulphinpyrazone was evaluated on Heart rate, blood pressure, and ventricular arrhythmias. Intravenous sulphinpyrazone reduced intrinsic heart rate by up to 15 beats/min and increased the duration of coronary occlusion without ventricular fibrillation in anaesthetized dogs.
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