Key result
hnRNP S1 proteins C2 and D2 associate with cytoskeletal vimentin filaments in cultured cells.
Why the study?
The association of hnRNP proteins with the cytoskeleton and their role in cytoplasmic mRNA localization and distribution was unclear.
Population
Cultured cells
Comparison
Monoclonal antibody specific to S1 proteins C2 and D2 vs no antibody
Design
Preclinical study using indirect immunofluorescence staining
Authors
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May indicate cytoskeletal roles for S1 proteins; leaves open functional significance pending validation.
This study provides the first evidence of hnRNP protein association with the cytoskeleton, specifically vimentin intermediate filaments.
Tsugawa et al. (1997) studied this question. The hnRNP S1 proteins C2 and D2 associate with vimentin intermediate filaments in the cytoplasm of cultured cells, representing the first report of hnRNP protein association with the cytoskeleton.
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