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The specific binding modes of hERG blockers remain poorly understood, presenting an ongoing challenge in drug design to prevent off-target interactions and serious cardiotoxicity.
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Discusses the binding modes of hERG blockers and their role in drug-induced cardiotoxicity.
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Kalyaanamoorthy et al. (2017) studied this question. The specific binding modes of hERG blockers remain poorly understood, presenting an ongoing challenge in drug design to prevent off-target interactions and serious cardiotoxicity.
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