Key result
SLE is linked to increased CIMT and lower orientation domain scores versus healthy subjects.
Why the study?
Systemic Lupus Erythematosus patients tend to have accelerated atherosclerosis which may contribute to cognitive impairment related to decreased cerebrovascular blood flow.
Do SLE patients have increased carotid intima-media thickness and impaired cognitive function compared to healthy subjects?
Cross-Sectional (n=121)
Do SLE patients have increased carotid intima-media thickness and impaired cognitive function compared to healthy subjects?
SLE patients exhibit increased carotid intima-media thickness and specific cognitive domain impairments compared to healthy subjects, suggesting accelerated atherosclerosis.
Answers are grounded in this paper and cite their sources.
Supports vascular-cognitive links in SLE but should not yet change practice; hypothesis-generating for longitudinal studies.
Background Systemic Lupus Erythematosus (SLE) patients tend to have accelerated atherosclerosis. It mayhave a role in the impairment of cognitive function related to a decrease in cerebrovascular blood flow. Methods Sixty SLE patients and 61 healthy subjects as participants underwent: history taking, physicalexamination, blood examination, medication, carotid Doppler ultrasound test, and cognitive function test.We compared Carotid Intima-media Thickness (CIMT) and Montreal Cognitive Assessment IndonesianVersion (MoCA-Ina) scores of the two groups. Result The comparison of the total MoCA-Ina scores between the two groups was not statistically significant ( p = .332). However, the orientation domain in the SLE group was statistically lower than the HS group (5.83 ± 0.41 vs 6 ± 0.00, p = .002). The SLE group was found to have a thicker anterior and posterior IMT of right carotid artery ( p < .001, p = .031) and a thicker anterior IMT of left carotid artery ( p < .001). There was a significant inverse correlation between the total MoCA-Ina score and the posterior IMT of the left carotid artery (r = −0.272, p = .035) of SLE patients. Atherosclerosis plaque of the right carotid artery was not associated with total MoCA-Ina score; however, there was a significant association with the attention domain ( p = .023) and the visuospatial domain of MoCA-Ina ( p = .018). Conclusion SLE patients have lower orientation domain of MoCA-Ina and thicker CIMT than healthy subjects. Atherosclerosis plaque of the carotid artery was associated with attention and visuospatial domains of MoCA-Ina.
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Gamayani et al. (2025) conducted a cross-sectional in Systemic Lupus Erythematosus (n=121). Systemic Lupus Erythematosus vs. Healthy subjects was evaluated on Total Montreal Cognitive Assessment Indonesian Version (MoCA-Ina) score (p=.332). Systemic Lupus Erythematosus was associated with thicker carotid intima-media thickness (p<0.001) and lower orientation domain scores (5.83 vs 6.00, p=0.002) compared to healthy subjects.
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