Key result
Cisplatin infusion is linked to recurrent complete AV block in a single patient case.
Case Report (n=1)
This is the first reported case of recurrent complete atrioventricular block developing as an acute cardiotoxic effect during cisplatin infusion.
Alerts clinicians to possible cisplatin-related recurrent AV block; first case leaves open causality and generalizability.
Cisplatin is one of the most effective chemotherapeutic agents used in the treatment of malignancies. The clinical use of cisplatin is limited by its severe adverse effects. Acute or long term cardiotoxicity is the most important doselimiting toxicity of cisplatin Cases of angina, myocardial infarction, and atrial arrhythmia have been reported during continuous infusion of cisplatin, but atrioventricular block (AV) has not been reported. Herein, we report a case with recurrent AV block that developed during cisplatin infusion, for the first time.
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Özcan et al. (2011) conducted a case report in Malignancy (n=1). Cisplatin infusion was evaluated on Recurrent complete atrioventricular block. Cisplatin infusion was associated with the development of recurrent complete atrioventricular block in a single patient case.
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